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B2.1Theme B — Form and function

Membranes and membrane transport — IB Biology SL Revision Notes & Topical Questions

5 min read 12 parts Lesson 4 of 13 2 quizzes

📚 IB Biology SL Hub / Topical Revision
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Curriculum Equation Key قوانين الرقم الهيدروجيني والاتزان الأيوني - pH & Acid-Base Equilibrium FormulasFast Exam Solution
pH = -log[H⁺] | pOH = -log[OH⁻] | pH + pOH = 14 | [H⁺][OH⁻] = 10⁻¹⁴
Word Equation & Conditions: الرقم الهيدروجيني = -لوغاريتم تركيز أيون الهيدروجين | pH + pOH = 14
Location & Specifications: الاتزان الأيوني، كيمياء 3 ثانوي، التحصيلي، و AP Chemistry.
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Lesson summary

B2.1 Membranes and membrane transport — IB BIOLOGY SL notes: Describe membrane structure and the processes by which substances cross membranes.Phospholipid — a glycerol, two fatty acid tails and a phosphate headThe head is polar and hydrophilic and the tails are non-polar and hyd…

  • Membranes everywhere
  • Integral proteins
  • Peripheral proteins
  • Protein content
  • Transport proteins
  • Selectivity

Part 1 of 10Phospholipid bilayer as a barrier

Phospholipid bilayer
Phospholipid bilayer
Phospholipid
  • Phospholipid a glycerol, two fatty acid tails and a phosphate head
  • The head is polar and hydrophilic and the tails are non-polar and hydrophobic.
  • This makes the molecule amphipathic.
Monolayer
  • Monolayer on a water surface the heads sit in the water and the tails point into the air
Bilayer
  • Bilayer with enough phospholipid, two layers form spontaneously with the tails meeting in the middle
  • The membrane is about 7-10 nm thick.
Barrier
  • Barrier the tightly packed hydrophobic core has a low permeability
  • Large molecules, polar molecules and ions are attracted to water and do not mix with the tails.
  • Small non-polar molecules such as O2 and CO2 cross freely.
  • Small polar molecules such as urea diffuse slowly.
Membranes everywhere
  • Membranes everywhere the plasma membrane and organelle membranes compartmentalise the cell and communicate between cells

Part 2 of 10Membrane proteins

Integral proteins
  • Integral proteins amphipathic and embedded in one or both layers
  • Their hydrophobic parts meet the lipid tails.
  • Examples are channel proteins.
Peripheral proteins
  • Peripheral proteins hydrophilic and attached to the surface
  • They bind to integral proteins or to a lipid anchor and can lie inside or outside the cell.
Protein content
  • Protein content it varies with function
  • Mitochondrial and chloroplast membranes are the most protein-rich because of their electron carriers.

Part 3 of 10Functions of membrane proteins

FunctionWhat it doesExample
TransportChannels and carriers move ions and polar moleculesAquaporins and glucose carriers
ReceptorBinds a signal and triggers events insideHormone and neurotransmitter receptors
Immobilised enzymeCatalyses reactions at the membraneDigestive enzymes on gut cells
Cell adhesionHolds neighbouring cells togetherCells joined within a tissue
RecognitionMarks a cell as selfABO antigens
Functions of membrane proteins
Transport proteins
  • Transport proteins each is specific to one ion or molecule, so the cell controls what enters or leaves
Receptors
  • Receptors bind peptide hormones such as insulin, neurotransmitters or antibodies

Part 4 of 10Simple diffusion

Simple diffusion
Simple diffusion
Diffusion
Diffusion the net movement of molecules or ions from a region of higher concentration to a region of lower concentration, caused by their random motion
  • Particles move down the concentration gradient until they reach equilibrium.
  • At equilibrium net movement stops although random motion continues.
Examples
  • Examples oxygen diffuses into respiring cells and carbon dioxide diffuses out
Rate of diffusion
  • A steeper concentration gradient gives a faster rate.
  • A higher temperature gives more kinetic energy and faster movement.
  • A larger surface area allows more crossing at once.
  • Small, uncharged, non-polar particles diffuse fastest.
Selectivity
  • Selectivity simple diffusion is selective only by size and polarity

Part 5 of 10Facilitated diffusion

Facilitated diffusion
Facilitated diffusion
Facilitated diffusion
Facilitated diffusion passive movement of large molecules, polar molecules and ions through transport proteins
  • It needs no energy and goes down the concentration gradient.
  • Each protein is highly specific for one substance.
Channel proteins
  • Channel proteins pores with a fixed shape that allow specific charged substances to pass
  • Gated channels open only with a signal such as voltage or a neurotransmitter.
Carrier proteins
  • Carrier proteins switch between two shapes
1
Glucose is more concentrated outside the cell.
2
Glucose binds to the open site of the carrier.
3
The carrier switches to its other shape.
4
The site now faces the cytoplasm.
5
Glucose is released inside the cell.
6
The empty carrier switches back.

Part 6 of 10Osmosis

Osmosis
Osmosis the net movement of water from a dilute solution to a more concentrated solution across a partially permeable membrane
  • It is a type of diffusion down the water concentration gradient.
  • It can also be described as movement from higher to lower water potential.
Aquaporins
  • Aquaporins channel proteins that let water cross more freely
  • Water is unusual for a polar molecule in passing directly between phospholipids.
Potato cylinder practical
1
Cut potato cylinders of the same size and place them in a range of sucrose solutions.
2
Keep the time and temperature the same.
3
Blot the cylinders dry and record the mass change.
4
Calculate percentage change = (final - initial) / initial × 100.
5
Find the isotonic point where the graph crosses zero change.

Part 7 of 10Active transport and selective permeability

Active transport
Active transport movement of molecules or ions across a membrane from lower to higher concentration using energy from respiration
  • It needs carrier proteins, called pumps.
  • ATP is hydrolysed to release energy that changes the shape of the pump.
  • Root cells take up mineral ions from dilute soil water in this way.
Selective permeability
  • Selective permeability membranes let some substances through and block others
  • Facilitated diffusion and active transport give the control.
  • Large or polar molecules cannot cross without transport proteins.

Part 8 of 10Transport methods compared

FeatureSimple diffusionFacilitated diffusionOsmosisActive transport
EnergyNoneNoneNoneATP required
DirectionDown the gradientDown the gradientTo higher solute concentrationAgainst the gradient
Protein neededNoChannel or carrierAquaporins speed it upPump
SubstancesO2, CO2, small non-polarIons and glucoseWaterNa+, K+, minerals
ExampleGas exchange in alveoliK+ channels in neuronsWater into root hair cellsSodium-potassium pump

Part 9 of 10Glycoproteins and glycolipids

Glycoprotein
  • Glycoprotein a membrane protein with a carbohydrate chain on the extracellular side
Glycolipid
  • Glycolipid a lipid with a carbohydrate chain, also on the outer surface
Functions
  • Receptors for hormones and neurotransmitters that trigger signalling.
  • Receptors for endocytosis.
  • Adhesion that holds cells together in tissues.
  • Markers (antigens) that let the immune system tell self from pathogen.

Part 10 of 10The fluid mosaic model

Fluid mosaic model
Fluid mosaic model
The fluid mosaic model
Fluid mosaic model
  • Fluid mosaic model proposed by Singer and Nicolson in 1972
  • Fluid, because phospholipids and proteins move within their own layers.
  • Mosaic, because the scattered proteins look like a mosaic from above.
Components
  • Components phospholipids, cholesterol, glycoproteins and glycolipids, and integral and peripheral proteins
Fluidity
  • Fluidity unsaturated fatty acid tails increase membrane fluidity
Drawing it
1
Draw two rows of phospholipid heads facing outwards.
2
Add paired tails meeting in the middle.
3
Insert an integral protein spanning both layers.
4
Place a peripheral protein on one surface.
5
Attach a carbohydrate chain on the outer side to make a glycoprotein.
6
Add cholesterol between the tails with its OH group near the heads and label every part.

Key terms

TermMeaning
AmphipathicHaving both a hydrophilic region and a hydrophobic region, as phospholipids do.
Integral proteinA membrane protein embedded in the bilayer.
Peripheral proteinA hydrophilic membrane protein attached to the surface.
Facilitated diffusionPassive movement down a concentration gradient through a transport protein.
OsmosisThe net movement of water across a partially permeable membrane from a dilute to a more concentrated solution.
Active transportMovement of substances against a concentration gradient using ATP and a carrier protein.
Fluid mosaic modelThe model of the membrane as a fluid phospholipid bilayer with scattered proteins.
Selective permeabilityThe property of letting some substances cross a membrane while blocking others.

Avoid these mistakes

1
Saying the membrane is a single layer — the phospholipids form a bilayer
2
Saying facilitated diffusion needs ATP — it is passive and goes down the gradient
3
Saying water moves to the more dilute side in osmosis — it moves to the more concentrated solution
4
Placing carbohydrate chains on the inner surface — they are on the outer surface

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