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Course: Cambridge AS & A Level Biology 9700 ...
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Cambridge AS & A Level Biology 9700 — Revision Notes

1 · Cell Structure

0/26

2 · Biological Molecules

0/51

3 · Enzymes

0/29

4 · Cell Membranes and Transport

0/41

5 · The Mitotic Cell Cycle

0/21

6 · Nucleic Acids and Protein Synthesis

0/22

7 · Transport in Plants

0/28

8 · Transport in Mammals

0/39

9 · Gas Exchange

0/13

10-11 · Infectious Disease and Immunity

0/43

12 · Energy and Respiration

0/37

13 · Photosynthesis

0/23

14-15 · Homeostasis and Control

0/57

16 · Inherited Change

0/34

17-18 · Selection, Evolution, Classification and Conservation

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19 · Genetic Technology

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Quiz

19.2.3 Gene Therapy – Exam questions

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  • Questions count: 12
  • Passing grade: B+
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1.
Gene therapy that treats only body cells is called _____.
germ-line
somatic
therapeutic cloning
transgenic
2.
Which statement best describes Gene therapy?
The legal framework deciding which techniques may be used, and on whom.
Treats the patient's body cells; the change is not passed to children.
Treating a disorder by supplying a working copy of a faulty gene.
An edit landing at an unintended site in the genome.
3.
Which statement best describes Somatic gene therapy?
A modified virus that delivers a gene into cells without causing disease.
Treats the patient's body cells; the change is not passed to children.
An animal carrying a gene from another species, often used in research or production.
An edit landing at an unintended site in the genome.
4.
Gene therapy outcomes for different disorders are shown. Which pattern explains the results?
Therapy succeeds best for single-gene disorders in accessible tissue
Therapy works best for polygenic disorders
Tissue accessibility does not matter
All disorders respond equally
5.
Protein levels after a single gene therapy dose are shown. What does the fall suggest?
The gene became more active
Treated cells are replaced over time, so repeat treatment may be needed
Therapy is permanent
The protein is made faster
6.
Which step belongs at '?' in the gene therapy sequence?
Dr Dabour Hub Academy - figure 1
The patient's gametes are edited
The faulty gene is copied by PCR into the embryo
Insulin is extracted from pigs
The vector delivers the gene to target cells, which express it
7.
In a trial of a new gene therapy, what is the purpose of a control group?
To give all patients the therapy
To compare outcomes against patients not receiving the therapy
To edit gametes
To increase side effects
8.
A gene therapy trial followed patients for only 3 months. What is the main weakness?
Too long
Trials need no follow-up
3 months is permanent
Long-term effects and safety are unknown
9.
Why must patients in gene therapy trials give informed consent?
Consent is optional
Relatives decide
Doctors are not responsible
They must understand the risks and benefits before agreeing
10.
A news report says a single case 'proves gene therapy cures cancer'. What is wrong?
One case is enough
Cancer is single-gene
One case cannot establish effectiveness; larger controlled trials are needed
Gene therapy is banned
11.
Why is it harder to treat cystic fibrosis lung cells than bone marrow cells with gene therapy?
Lungs have no cells
Bone marrow has no DNA
Lung lining is hard to reach, while marrow cells can be removed, treated and returned
CF is polygenic
12.
Which safeguard best addresses unequal access to gene therapies?
Allowing only the wealthy access
Banning all therapies
Ignoring costs
Deliberate policies to fund and distribute treatment fairly
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Part of 19 · Genetic Technology — see every lesson and quiz in this unit.
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