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A2.1Theme A — Unity and diversity

Origins of cells — IB Biology SL Revision Notes & Topical Questions

5 min read 13 parts Lesson 7 of 11 1 quiz

📚 IB Biology SL Hub / Topical Revision
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Curriculum Equation Key قوانين الرقم الهيدروجيني والاتزان الأيوني - pH & Acid-Base Equilibrium FormulasFast Exam Solution
pH = -log[H⁺] | pOH = -log[OH⁻] | pH + pOH = 14 | [H⁺][OH⁻] = 10⁻¹⁴
Word Equation & Conditions: الرقم الهيدروجيني = -لوغاريتم تركيز أيون الهيدروجين | pH + pOH = 14
Location & Specifications: الاتزان الأيوني، كيمياء 3 ثانوي، التحصيلي، و AP Chemistry.
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Lesson summary

A2.1 Origins of cells — IB BIOLOGY SL notes: Describe the conditions, steps and evidence for the origin of the first cells, LUCA and endosymbiosis.Cell = the smallest unit that can carry out all the functions of lifeEvery cell is enclosed by a plasma membrane.Every cell stores ge…

  • Greenhouse gases
  • UV radiation
  • Meteorites
  • Primordial soup
  • Protocell-first
  • Gene-first

Part 1 of 10Cells as the smallest units of life

Cell
Cell the smallest unit that can carry out all the functions of life
  • Every cell is enclosed by a plasma membrane.
  • Every cell stores genetic information in DNA, which is expressed during protein synthesis.
Functions of life
  • Functions of life metabolism, growth, response to stimuli, homeostasis, reproduction, excretion and nutrition
Viruses
  • Viruses not cells, because they lack metabolism, need no nutrition and rely on host cells to replicate

Part 2 of 10The challenge of the first cell

1Problem
  • Problem cells arise only from pre-existing cells, so the first cell had to arise without one
2Age
  • Age the Earth is about 4.5 billion years old and fossil evidence of cells goes back at least 3.5 billion years
3
Steps needed to make a cell
  • Simple organic compounds must be made from inorganic molecules.
  • The organic compounds must be assembled into polymers.
  • Some polymers must be able to self-replicate.
  • Membranes must surround the polymers to make a compartment with its own internal chemistry.
4Evidence
  • Evidence no direct evidence of the first cells survives, so models remain hypotheses

Part 3 of 10Conditions on the early Earth

ConditionEarly EarthModern EarthRelevance
Free oxygenAlmost noneAbout 21%Organic molecules were not oxidised
Main gasesCO2, N2, H2O, with CH4 and NH3 proposedN2 and O2Supplied C, H and N
Ozone layerAbsentPresentHigh UV energy reached the surface
EnergyLightning, UV, volcanic heatMainly sunlightDrove synthesis reactions
TemperatureHot and very variableMildFaster reactions
Greenhouse gases
  • Greenhouse gases high CO2 and methane raised surface temperatures
UV radiation
  • UV radiation with no ozone it reached the surface, damaged DNA and drove the formation of organic molecules
Water
  • Water oceans and tidal pools concentrated the reactants as they evaporated
Vents
  • Vents deep-sea alkaline vents offered heat, minerals and chemical gradients
Meteorites
  • Meteorites some carry amino acids and may have seeded the Earth with organic molecules
Primordial soup
Primordial soup the Oparin-Haldane idea that early oceans held a rich mix of simple organic compounds
  • Amino acids, simple sugars, nucleotides and fatty acids could have formed from heat or UV acting on the gases.

Part 4 of 10Theories for the origin of cells

1Protocell-first
  • Protocell-first cell-like compartments able to grow and divide arose first and later gained genetic material, probably RNA
2Gene-first
  • Gene-first a self-replicating nucleic acid, probably RNA, arose first and variants later developed membranes and metabolism
3Metabolism-first
  • Metabolism-first a self-sustaining system of chemical reactions arose first and later evolved into cells and genetic material
  • Many scientists favour it because life processes need energy from metabolic reactions.
4Testing
  • Testing the theories are hard to test
  • Early Earth conditions cannot be copied exactly.
  • The first cells were not fossilised.

Part 5 of 10Membranes and vesicles

Membranes and vesicles
Compartmentalisation
  • Compartmentalisation a membrane separates the genetic material and biochemistry from the surroundings
Fatty acids
  • Fatty acids likely first membrane molecules because they are amphipathic
  • In water a few lipid molecules form a monolayer at the surface.
  • More lipid forms bilayers with polar parts facing the water and non-polar tails facing each other.
  • Bilayers spontaneously form microspheres or vesicles with hydrophobic tails inwards.
Later evolution
  • Later evolution fatty acids could combine with glycerol to form triglycerides and then phospholipids, the main component of modern membranes

Part 6 of 10RNA as the first genetic material

Ribosome translating messenger RNA
Ribosome translating messenger RNA
1Needs of early life
  • Needs of early life a system that could replicate itself and a way to catalyse reactions
2RNA world hypothesis
  • RNA could both store genetic information and act as an enzyme
  • RNA folds into ribozymes that catalyse reactions.
  • DNA later took over storage because it is chemically more stable.
  • Proteins became the catalysts.
3
Evidence for RNA before DNA
  • RNA can assemble spontaneously from nucleotides and can replicate itself.
  • Ribose can be formed from methanal, a product of the Miller-Urey experiment.
  • Deoxyribose is made from ribose in an enzyme-catalysed reaction.
  • Ribozymes can join amino acids into proteins using an RNA template, and ribosomes still use RNA as their catalytic core.
4Fragility
  • RNA is chemically fragile

Part 7 of 10LUCA

LUCA
LUCA the last universal common ancestor, a single-celled organism that lived about 4 billion years ago
  • It sits at the base of the phylogenetic tree of life.
Evidence
  • All organisms share the same DNA bases, the same genetic code and the same amino acids in proteins.
  • Several genes are shared by eubacteria and archaea, so they were inherited from LUCA.
  • Organisms with similar DNA are more closely related than those with very different DNA.
Other early life
  • Other early life other organisms probably existed then but left no descendants
  • Descendants of LUCA outcompeted them for shared resources.
Dating
  • Dating fossils and rocks are dated by radiometric methods, and the molecular clock uses the rate at which mutations accumulate
  • Numbers from fossils and the molecular clock are estimates, not exact dates.

Part 8 of 10LUCA and hydrothermal vents

Habitat
  • LUCA may have lived near deep-sea hydrothermal vents, where chemosynthesis can supply energy
Fossil evidence
  • Fossil evidence haematite tubes in sedimentary rocks near vents in Quebec resemble structures made by modern iron-oxidising prokaryotes
  • Stromatolites and microfossils also show early prokaryotes.
Gene evidence
  • Gene evidence sequence data from modern vent species show a common ancestor
Likely features of LUCA
  • Anaerobic.
  • Converted carbon dioxide into glucose.
  • Used hydrogen as an energy source instead of sunlight.
  • Converted nitrogen into ammonia for amino acids.
  • Thermophilic, surviving very high temperatures.
Alternative hypotheses
  • Alternative hypotheses scientists continue to gather data that may support or refute this view

Part 9 of 10Endosymbiosis

Endosymbiosis
Endosymbiosis one cell living inside another, which explains the origin of mitochondria and chloroplasts
  • A large cell engulfed an aerobic bacterium that became the mitochondrion.
  • A later engulfed photosynthetic bacterium became the chloroplast.
Evidence
  • Evidence both organelles have a double membrane, their own circular DNA, 70S ribosomes and divide by binary fission
Common origin
  • Common origin it explains why all eukaryotes share a common origin

Part 10 of 10More from the specification

  • Theory
    • A well-tested explanation supported by a large body of evidence.

Key terms

TermMeaning
Primordial soupThe idea that early oceans held a rich mix of simple organic compounds.
Miller-Urey experimentA 1950s laboratory simulation showing amino acids can form from simple gases with an energy input.
VesicleA small sphere bounded by a lipid bilayer that forms spontaneously from fatty acids in water.
RNA worldThe hypothesis that early life used RNA both to store information and to catalyse reactions.
RibozymeAn RNA molecule that acts as a catalyst.
LUCAThe last universal common ancestor from which all living organisms descend.
Hydrothermal ventA crack in the sea floor releasing hot mineral-rich water, a proposed site for early life.
EndosymbiosisThe origin of mitochondria and chloroplasts from bacteria engulfed by a larger cell.

Avoid these mistakes

1
Saying that the Miller-Urey experiment created life — it only made simple organic molecules
2
Thinking viruses are cells — they lack metabolism and cannot reproduce without a host
3
Saying LUCA was the only organism alive at that time — other organisms probably existed but left no descendants
4
Thinking DNA came before RNA — RNA is thought to have been the first genetic material

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Cambridge 9700 AS Biology Core Formula

Magnification Triangle & Unit Conversion

Formula: M = I / A  ⇔  A = I / M  ⇔  I = M × A

Units: 1 mm = 1,000 μm = 1,000,000 nm.
Rule: Convert Image size (ruler mm) to μm by ×1,000 before dividing by Actual size.

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